Eyewire II is a groundbreaking effort to map an entire mouse retina at an unprecedented level of detail. With this, we aim to build an open community of scientists, engineers, and volunteers to map the neural circuits of the mouse retina at the ultrastructural level. / 

This page is a collection of some of the cell classes that have been identified in the volume. For a complete listing of cell types, see this spreadsheet.

Forum /  Find Cells to Map for citizen scientists

Starburst Cells

These starbursts span the ON and OFF layer. They are currently being proofread by citizen scientists. View in neuroglancer.

HCs (Horizontal Cells)

 

Muller Cells

Bipolar cells and Ganglion Cell (green)

 

Bistratisfied Ganglion Cell

 

Multiple cell types in one view

Bipolar Cells (yellow, different types), Ganglion Cells (blue), and Horizontal cells (pink) with photoreceptor shown in purple. View in 3D

 

Eyewire II offers a unique opportunity for scientists and citizen scientists to contribute to the detailed mapping of retinal structures using cutting-edge technology, while answering their own exciting research questions. If you are a citizen scientist, get on the wait list here.

If you are a researcher, you can request early access at eyewire.ai.

By participating in neuron tracing and data analysis, you not only help advance our understanding of retinal wiring but also become part of a collaborative network with access to valuable insights. Joining Eyewire II allows you to engage in meaningful scientific discovery, potentially contributing to future publications and breakthroughs in the field.

The dataset comprises a 1-by-1 mm area of a mouse retina, currently spanning from the ganglion cell layer (GCL) into the inner nuclear layer, at some spots already reaching into the outer plexiform layer (OPL). In the long run, the plan is to complete the volume such that it includes the OPL across the whole field. The voxel size is 8x8x40 nm; the tissue is conventionally stained and includes synapses. Moreover, it contains 5 recording fields (each approx. 90-by-90 microns) where the responses of the GCL to a set of visual stimuli (i.e. chirps, moving bars, natural movies) were recorded using 2P Ca2+ imaging.